No needles. No fridge. One patch a week.
24.2% mean weight reduction at 48 weeks — retatrutide Phase 2 trial, NEJM 2023. Trial used the injectable form. Individual results vary.
Retatrutide Phase 2 trial in adults with obesity, published in The New England Journal of Medicine, 2023 · NCT04881760. Highest dose, 48 weeks. The trial used the injectable form of the compound. Individual results vary.
Semaglutide works on one receptor. Tirzepatide works on two. Retatrutide is the first to engage all three.
Figures are from three separate trials, not a head‑to‑head study — populations, doses and durations differ, so the columns are not strictly comparable. STEP 1 (semaglutide, NEJM 2021) · SURMOUNT‑1 (tirzepatide, NEJM 2022) · retatrutide Phase 2 (NEJM 2023). All three trials used the injectable form. Individual results vary.
An injection puts everything in at once. A transdermal reservoir hands it over slowly, through the skin, for as long as the patch is on.
A micro-textured layer inside the patch holds the compound against the skin at a constant concentration.
Skin temperature and the concentration gradient between patch and tissue drive a slow, continuous hand-off through the outer skin barrier.
Below the epidermis, the dermal capillary bed picks it up and moves it into circulation — steadily, over days rather than minutes.
Simplified illustration of transdermal delivery. Not to scale and not a depiction of measured release from any specific product.
Injections work. But they ask a lot of you: a weekly needle, a fridge you have to plan your life around, vials and syringes, and a sharp peak that fades before the next dose.
Most people don't quit because it stopped working. They quit because the routine wore them down.
So we moved the delivery to the skin. A transdermal reservoir releases steadily through the skin barrier across the week — no needle, no cold chain, no daily decision to make.
You put it on once. It does the rest.
The patch holds its payload in a micro-textured reservoir. Body heat and the skin gradient do the rest — a slow, even hand-off instead of a single sharp dose.
Take the patch off its liner. No mixing, no measuring, nothing to draw up.
Press it to a clean, dry spot — upper arm, shoulder or abdomen. It stays put through showers and workouts.
Change it once a week. That's the entire routine.
Where a member’s own progress sits — the earlier photograph ghosted behind, the current one forward, patch visible.
This is the composition only, so the team can judge the device: the earlier figure ghosted behind, the current figure sharp in front with the patch showing.
To go live it needs real photographs of consenting customers — same pose, same lighting, same clothing, week 0 and week 12, with the dates recorded.
Individual results vary. Photographs are of real customers, used with permission, and are not a guarantee of any particular outcome.
| Injections | Themis patch | |
|---|---|---|
| How often | Every week, on schedule | Once a week, whenever suits |
| Needles | Yes — and sharps disposal | None |
| Storage | Refrigerated | Room temperature |
| Travelling with it | Cool bag, careful planning | Slip it in a wallet |
| Delivery pattern | Sharp peak, then a trough | Steady across the week |
| Preparation | Draw up, measure, dose | Peel and place |
HPLC and mass spec on every lot, with a Certificate of Analysis you can actually read.
Warehoused in Utah and Houston. Orders leave fast and reach all fifty states.
A reservoir designed for steady hand-off, not a burst that fades by day two.
It's about the size of a coin, sits flat under a sleeve, and stays on through showers, workouts and sleep. Most people put it on Sunday morning and don't think about it again until the next one.
These three cards are placeholders. Drop in genuine reviews with real names — invented testimonials are the fastest way to lose a customer's trust and land you in trouble.
A real customer quote goes here — two or three sentences, specific about what changed for them.
A real customer quote goes here — two or three sentences, specific about what changed for them.
A real customer quote goes here — two or three sentences, specific about what changed for them.
Two minutes. No consultation to book, no waiting room, no phone call.
A flat box at room temperature. No cold pack, no signature, nothing to sign for.
Three seconds on a clean patch of skin. Rotate the spot each week.
Skip it, pause it or cancel it from your account whenever you like.
Every plan ships free, arrives at room temperature, and can be paused or cancelled whenever you like.
Free shipping · pause or cancel any time · [XX]-day money-back guarantee
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Anywhere clean, dry and relatively hair-free — upper arm, shoulder or abdomen are the usual spots. Rotate the site each week so the skin gets a break.
Yes. The adhesive is designed for a full week of ordinary life, including showering, sweating and sleeping.
No. It ships and stores at room temperature, which is what makes travelling with it straightforward.
Every lot goes through HPLC and mass-spec analysis, and ships with a Certificate of Analysis. Ask us and we'll send you a sample COA before you order.
Any time, from your account or by replying to any email we send you. No phone call, no retention script.
Appetite is usually the first thing people mention, within the first week or two. Changes on the scale build more slowly — the trial behind the figures on this page ran for 48 weeks. Some people notice less than others, and we would rather say that plainly than promise you a number.
Plenty of people come to the patch after a stretch on a weekly injection, usually because of the needles, the fridge or the travelling. Talk it through with whoever prescribed your current treatment before you change anything.
Don’t use it if you are pregnant, nursing or trying to conceive. Speak to a doctor first if you have a personal or family history of medullary thyroid carcinoma or MEN 2, pancreatitis, gallbladder or significant gastrointestinal disease, or if you take any prescription medication. In the trials, the most common side effects were nausea, diarrhoea, vomiting and constipation.
[Placeholder — this answer changes completely depending on whether the patch is sold direct or through a telehealth provider. Confirm the model before launch.]